complementtech C1 是级联中的第一个补体成分,称为补体经典途径。C1 与抗原(免疫复合物)结合的抗体结合并被其激活,从而产生启动级联反应的蛋白酶。C1 实际上是三种不同蛋白质(C1q、C1r 和 C1s)在钙依赖性复合物中结合在一起的非共价复合物。C1q 通过其六个臂中的两个或多个与 IgG 或 IgM 的 Fc 结构域结合。多臂与免疫复合物的结合被认为会引入压力,导致复合物中的两种 C1r 蛋白(蛋白酶原)自动激活自身,产生两种活性 C1r s氨酸蛋白酶(Morikis, D. 和 Lambris, JD (2005)) . 这些活化的 C1r 亚基切割并激活复合物中的两个 C1s 蛋白酶酶原。活化的 C1s 裂解补体成分 C4,释放 C4a 并启动 C4b 与活化表面的共价连接。活化的 C1s 也切割 C2,C2 的较大片段与表面连接的 C4b 结合,形成 C4b、C2a,它是经典途径的 C3/C5 转化酶。
ComplementTech现货列表
货号 |
品名 | 规格 | 品牌 |
---|---|---|---|
A113-250 ug/vial | C3 Protein | 250 ug/vial | ComplementTech |
A104 | C1s Enzyme 1.0 mg/ml | 250 ug/vial | ComplementTech |
R114 | Rat C3b *(NEW)* | 100ug | ComplementTech |
M099 | Mouse C1q | 100ug/vial | ComplementTech |
A099 | C1q Protein | 1000 ug/ vial | ComplementTech |
A113c | C3 (concentrated) 5.0 mg/ml | 1000 ug/vial | ComplementTech |
A127 | SC5b-9 Complex 1.0 mg/ml | 100ug | ComplementTech |
A124 | C7 Protein | 250 ug/via | ComplementTech |
A125 | C8 Purified Human Complement Protein | 250ug/vial | ComplementTech |
A106 | C4a 0.5 mg/ml | 50ug/vial | ComplementTech |
A336 | Factor D-Dpl | 1ml/vial | ComplementTech |
A108 | C4b 1.0 mg/ml | 250ug/vial | ComplementTech |
A117 | C3d | 100ug/vial | ComplementTech |
A119 | C3a desArg | 50ug/vial | ComplementTech |
A100 | C1q (40% Glycerol) | 1mg | ComplementTech |
A122 | C5b,6 Complex | 50 ug/vial | ComplementTech |
A126 | C9 Protein | 250 ug/vial | ComplementTech |
C1040 | C1s-C1INH Complex *(NEW)* | 50 ug/vial | ComplementTech |
A098 | C1 0.2 mg/ml | 200 ug/vial | ComplementTech |
A103 | C1s Proenzyme 1.0 mg/ml | 250 ug/vial | ComplementTech |
A323 | C6-Dpl | 1ml | ComplementTech |
A115 | iC3b蛋白 | 250ug | ComplementTech |
A235 | Goat Anti-Human Factor B | 1ml | ComplementTech |
A118 | C3a | 50ug/vial | ComplementTech |
NHS | Human Serum | 1.0 ml/vial | ComplementTech |