Innovative Research of America(IRA)—药物定量定时缓释系统
Innovative Research of America(IRA) 是一家致力研发于药物定量定时缓释系统的专业化公司，又称Matrix-Driven Delivery (MDD) 给药系统。该给药系统由一个可生物吸收的基质组成，含有定量可控的活性给药成分，可以以设定的剂量在一定时间范围内进行给药。
给药天数及剂量的选择：依据研究人员实验需要确定，如某实验需要在3周内给大鼠皮下给某种药x mg，首先在本公司产品目录中选取该种药物，然后选取21天缓释时间，剂量选择可以如下方式进行：21天共给药量或每天给药量，计算出总的药物剂量。本公司常规的给药时间有21，,60，90天，即可选择21天的给药时间（如常规给药时间不满足实验设计，可公司进行产品定制）。同样，给如本公司提供的常规给药剂量不满足实验设计，也可公司进行产品定制。本公司可根据客户需要在给药系统中加入可在规定期间释放一定剂量的活性药物。
给药方法：皮下（一般选取背部或颈部皮肤松弛部位）植入本给药系统。手工植入方法为选取植入部位，切开一个药丸直径相当的切口，以无菌镊子自切口探入，深入皮下至2cm处，用镊子将药丸送入离切口2cm处，缝合切口即可。切忌：（1）切口及镊子探入时伤及肌肉层，可引起炎症，影响药物释放及实验；（2）镊子送入药丸时切勿破坏药丸，否则影响药丸缓释效应，影响实验结果。
使用套针给药（另售）：将药丸放入给药套针，选取给药点，扎入针头，在不伤及肌肉的情况下将针深入扎入处2cm，将药丸推入皮下，抽出套针即可，无需缝合。
相关参考文献：
1. BARAZZONE-ARGIROFFO, MUZZIN, DONATI, KAN, AUBERT, PIGUET. AMERICAN JOURNAL OF PHYSIOLOGY: LUNG, CELLULAR AND MOLECULAR PHYSIOLOGY, 281 (5) : pp.L1150-L1156, 2001.Product.NADOLOL – Dosage 0.5 MG – Release Time 21-DAY – Pellet Type: Stock
2. GARCIA, DEBINSKI, GUTKOWSKA, KUCHEL, THIBAULT, GENEST, CANTIN. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 131 (2) : pp.806-814, 1985. Product. DEOXYCORTICOSTERONE ACETATE (DOCA) – Dosage 25MG – Release Time 21-DAY – Pellet Type: Stock.
3. DAMASSA, GUSTAFSON, KWIECINSKI, PRATT. BIOLOGY OF REPRODUCTION, 33 (5) : pp.1138-1146, 1985. Product. D-THYROXINE – Dosage 0.5MG – Release Time 21-DAY – Pellet Type: Stock.
4. WASHBURN, KRANTZ, AVERY, REEDLAND.FASEB ABSTRACT FORM 535-5, 1990. 17ß-ESTRADIOL – Release Time 21-DAY – Pellet Type: Stock.
5. TOKARZ. HORMONES AND BEHAVIOR, 21 (3) : pp.358-370, 1987. Product. CORTICOSTERONE – Dosage 0.1MG – Release Time 21-DAY – Pellet Type: Stock
6. REES, PANESAR, STEINER, FLEMING. HORMONES AND BEHAVIOR, 46 (4) : pp.411-419, 2004. Product. CORTICOSTERONE – Dosage 75MG – Release Time 21-DAY – Pellet Type: Stock
7. GORDON, SHELNESS, NICOSIA, WILLIAMS. JOURNAL OF BIOLOGICAL CHEMISTRY, 263 (6) : pp.2625-2631, 1988. Product. 17ß-ESTRADIOL – Dosage 100MG – Release Time 21-DAY – Pellet Type: Stock.
8. CONNOR, SAWCZUK, BENSON, TOMASHEFSKY, O'TOOLE, OLSSON, BUTTYAN. PROSTATE, 13 (2) : pp.119-130, 1988. Product. VERAPAMIL – Dosage 100MG – Release Time 21-DAY – Pellet Type: Stock
9. MOR, ZAINO, SATYASWAROOP. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 162 (4) : pp.928-936, 1990. Product. 17ß-ESTRADIOL – Dosage 200 PG/ML – Release Time 60-DAY – Pellet Type: Stock.
10. SATYASWAROOP, ZAINO, MOR. CANCER AND MATASTISIS REVIEWS, 6 : pp.223-241, 1987. Product. 17ß-ESTRADIOL – Dosage N/A – Release Time 60-DAY – Pellet Type: Stock
11. WANG, NAN, YU, AGRAWAL, ZHANG. CLINICAL CANCER RESEARCH , 7 (11) : pp.3613-3624, 2001. Product. 17ß-ESTRADIOL – Dosage 1.7MG – Release Time 60-DAY – Pellet Type: Stock
12 .BIANCO, STRIZZI, EBERT, CHANG, REHMAN, NORMANNO, GUEDEZ, SALLOUM, GINSBURG, SUN, KHAN, HIROTA, WALLACE-JONES, WECHSELBERGER, VONDERHAAR, TOSATO, STETLER-STEVENSON, SANICOLA, SALOMON. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 97 (2) : pp.132-141, 2005. Product .17ß-ESTRADIOL – Dosage 0.72 MG – Release Time 60-day – Pellet Type: Stock.
13. ZAINO, SATYASWAROOP, MOR. SCIENCE, 219 (4580) : pp.58-60, 1983. Product. 17ß-ESTRADIOL – Release Time 60-DAY – Pellet Type: Stock
14. ENGELSON, PI-SUNYER, KOTLER. NUTRITION, 15 (6) : pp.465-473, 1999. Product. MEGESTROL ACETATE – Dosage 50 MG – Release Time 90-DAY – Pellet Type: Stock and TESTOSTERONE PROPIONATE – Dosage 35 MG – Release Time 90-DAY – Pellet Type: Stock.