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Anti-PEG 抗体是在中国科学院生物医学研究所发明的。
由于这个原因，我们的抗体有时被称为“中华人民共和国”抗PEG抗体。
中央研究院成立于1928，至今仍是中国台湾zui早的研究机构之一。
中央研究院位于台北首都中国台湾的东部。
Anti-PEG antibodies
To allow sensitive measurement of PEGylated compounds, we developed the first monoclonal antibodies (AGP3 and E11) with specificity for PEG in 1999. These antibodies can be employed to measure PEG-modified protein by ELISA.
Since that time, we have generated additional high affinity anti-PEG monoclonal antibodies.
AGP4 and rAGP6 are high affinity IgM antibodies that can effectively capture PEGylated compounds for sensitive detection by ELISA.
3.3 is a IgG anti-PEG antibody that is compatible with wash buffers containing Tween 20 detergent.
6.3 and r33G are high affinity IgG antibodies that provide sensitive detection of PEGylated compounds.
15-2b is a high affinity antibody that binds to methoxy PEG.
We also recently developed a temperature responsive anti-PEG antibody (2B5) that can reversibly bind and release PEG by thermal cycling.
IgG antibodies
E11 is a first generation IgG mouse monoclonal antibody that specifically binds to the backbone (repeating ethylene oxide subunits) of PEG.
3.3 is a higher affinity anti-PEG monoclonal antibody. It is compatible with buffers containing Tween-20.
6.3 binds with high affinity to PEG but cannot be used with buffers containing Tween-20.
15-2b binds with high affinity to the terminal methoxy group of mPEG.
r33G is a rat IgG monoclonal antibody that binds a wide spectrum of PEG molecules with high affinity. It can be used with Tween-20.
IgM antibodies
AGP3 is a first generation IgM monoclonal antibody that specifically binds to the backbone of PEG.
AGP4 is a higher affinity anti-PEG IgM monoclonal antibody. It works well for capture of PEGylated compounds in ELISA.
rAGP6 is a rat IgM monoclonal antibody that binds with the highest affinity to PEG.
These antibodies can be employed to detect and quantify PEG-modified molecules in immunoblots, by ELISA and by flow cytometry.