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产品编号 D50679
英文名称 LY 294002
中文名称
别    名   2-吗啉代-8-苯基-4-氧代-4H-1-苯并吡喃; LY294002/PI3K抑制剂;
Specific References  (2)     |     D50679 has been referenced in 2 publications.
[IF=5.131] Kang Lu. et al. Micropattern Silk Fibroin Film Facilitates Tendon Repair In Vivo and Promotes Tenogenic Differentiation of Tendon Stem/Progenitor Cells through the α2β1/FAK/PI3K/AKT Signaling Pathway In Vitro. STEM CELLS INT. 2023 Jan 13;2023:2915826  
PubMed:36684388

[IF=2.813] Lu, Kang. et al. N-Acetyl-L-cysteine facilitates tendon repair and promotes the tenogenic differentiation of tendon stem/progenitor cells by enhancing the integrin α5/β1/PI3K/AKT signaling. BMC MOL CELL BIOL. 2023 Dec;24(1):1-13  
PubMed:36604630

保存条件 Store at -20℃ for 3 year(Powder); In DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 CAS：154447-36-6
分子式：C19H18ClNO3
分子量：343.8
MDL：MFCD00270881
纯度：≥99.95% (HPLC)
溶解性：溶于DMSO,
作用靶点：PI3K; Casein Kinase; DNA-PK; Autophagy; Apoptosis;
作用通路：PI3K/Akt/mTOR; Cell Cycle/DNA Damage; Stem Cell/Wnt; Autophagy; Apoptosis;
产品描述：LY294002 是一种广谱 PI3K 抑制剂，抑制 PI3Kα, PI3Kδ 和 PI3Kβ 的 IC50 分别为 0.5, 0.57, 0.97 μM。LY294002 也可抑制 CK2 的活性，IC50 为 98 nM。LY294002 是一种竞争性 DNA-PK 抑制剂，可逆结合 DNA-PK 的激酶结构域，IC50 为 1.4 μM。LY294002 是一种自噬 (autophagy) 和凋亡 (apoptosis) 激活剂。