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Mitomycin C
货号: BIA-M1183
规格: 5 mg, 25 mg
Synonyms : Mitomycin, Mitomycin S, Mitiromycin E, Ametycine, Mitocin C, Mutamycin, NSC 26980
Specifications
|
CAS |
50-07-7 |
|
Molecular Formula |
C15H18N4O5 |
|
Molecular Weight |
334.3 |
|
Source |
Streptomyces sp. |
|
Appearance |
Blue solid |
|
Purity |
>98% by HPLC |
|
Long Term Storage |
-20°C |
|
Solubility |
Soluble in ethanol, methanol, DMF or DMSO. Moderate water solubility. |
Application Notes
Mitomycin C is the most studied of a family of highly distinctive blue/purple metabolites produced by several Streptomyces species. Mitomycin C exhibits potent antibacterial and antitumor activity and inhibits DNA synthesis by intercalation, blocking nuclear division with the induction of apoptosis in cancer cells.
References
- Mitomycin, a new antibiotic from Streptomyces. I. Hata T. et al., J. Antibiot. 1956, 9, 141.
- DNA sequence specificity of mitomycin cross-linking. Teng S.P. et al., Biochemistry 1969, 28, 3901.
- Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95- independent manner in human gastric adenocarcinoma cells. Park I.C. et al., Cancer Lett. 2000, 158, 125.
- Activation of the S phase DNA damage checkpoint by mitomycin C. Mladenov E. et al., J. Cell. Physiol. 2007, 211, 468.