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Endonuclease III (Nth)
- Bifunctional DNA glycosylase with DNA N-glycosylase and AP lyase activities
- The N-glycosylase activity releases damaged pyrimidines, including thymine glycol and 5, 6-dihydroxythymine, generating an AP site. The AP lyase activity cleaves an AP site via β-elimination, creating a 1-nucleotide gap with 3′-α, β-unsaturated aldehyde and 5′-phosphate termini
