标签归档：毒素

listlabs 炭疽毒素说明书

发表于由

list biological laboratories公司是世界的科研毒素试剂供应商，其毒素包括霍乱病毒，蛇毒，百日咳毒素等各类毒素,我公司常年低价供应,货期快.有意者请. 百日咳毒素长期现货供应，货号181及180。

 

listlabs 炭疽毒素说明书

炭疽毒素Anthrax Toxins

 

炭疽杆菌是炭疽病的病原体。炭疽杆菌产生的主要毒力因子是γ连接的聚-D-谷氨酸胶囊和由三种成分组成的外毒素，保护性抗原（PA），致死因子（LF）和水肿因子（EF）。这些蛋白质不是单*毒的，而是以二元组合起作用。PA（细胞结合成分）与LF（酶部分之一）的复合物被称为“致死毒素”并可导致死亡。PA和酶促EF一起引起皮肤水肿。分泌后，PA被膜肽酶切割，使63kDa羧基末端片段寡聚化成七聚体。切割是暴露EF和LF的结合位点的必要步骤。组装的PA复合物和相关的LF或EF通过胞吞作用进入细胞。PA介导LF和EF向细胞质的转移，其中这些酶识别并蛋白水解其靶标。LF组分是一种锌依赖性金属蛋白酶，可裂解丝裂原活化蛋白激酶激酶（MAPKK），从而削弱其功能，从而阻断MAPK信号通路。EF是钙调蛋白依赖性腺苷酸环化酶，其在细胞中产生过量的环AMP，导致水肿。目前的研究集中于开发有效的疫苗以及筛选LF酶活性的有效抑制剂。

含有炭疽LF切割位点的FRET肽底物可作为MAPKKide®获得，并可用于评估LF的酶活性。

炭疽毒素

（炭疽水肿因子）

水肿因子（EF）是钙调蛋白依赖性腺苷酸环化酶，其可在易感细胞内产生过量的腺苷酸环化酶。List Labs提供两种形式的EF，它们都是在天然炭疽芽孢杆菌宿主中重组制备的。产物＃178由天然序列组成，在N-末端具有另外的氨基酸组氨酸。产物＃173的突变体EF S414N具有降低的腺苷酸环化酶活性，并且已显示其充当佐剂。

炭疽毒素

（炭疽水肿因子）

 

炭疽水肿因子（EF），来自炭疽杆菌的
重组体

窗体顶端

产品＃和尺寸

＃178A（0.1毫克） – 160.00美元

 

 

 

炭疽毒素

（炭疽水肿因子）

 

来自炭疽芽孢杆菌的炭疽水肿因子（EF），
重组，突变体S447N

 

产品＃和尺寸

＃173B（0.5毫克） – 950.00美元

 

 

货号

品名

 规格

价格

list104

Cholera Toxin B Subunit (Choleragenoid) in low salt1

0.5mg

4930

list106

Cholera Toxin B Subunit Fluorescein Isothiocyanate Conjugate (BFITC)

0.2mg

9775

list112

Cholera Toxin B Subunit Biotin

0.2mg

9775

list122

Enterotoxin Type B from Staphylococcus aureus1,3

0.5mg

7225

list123

Enterotoxin Type B Toxoid from Staphylococcus aureus  1,3

0.25mg

8075

list139

Botulinum Neurotoxin Type B Toxoid

10µg

6800

list150

Diphtheria Toxin, unnicked from Corynebacterium diphtheriae

1mg

11050

list151

Diphtheria Toxoid, from Corynebacterium diphtheriae

0.5mg

10625

list153

Toxin A Toxoid from Clostridium difficile

100µg

11900

list156

Pasteurella Multocida Toxin

50µg

8075

list160

Exotoxin A from Pseudomonas aeruginosa

1mg

4420

list161

Shiga Toxin 1 from Escherichia coli1,4,8

10µg

11900

list162

Shiga Toxin 2 from Escherichia coli1,4,8

10µg

11050

list174

Anthrax Protective Antigen, Activated (PA 63) from Bacillus anthracis

0.5mg

9350

list175

Anthrax PA 63 – Fluorescein Isothiocyanate Conjugate (PAFITC)

50µg

7225

list180

Pertussis Toxin Islet-Activating Protein Lyophilized in buffer

50µg

5525

list181

Pertussis Toxin Islet Activating Protein Lyophilized (Salt-Free)

50µg

5525

list184

Pertussis Toxin Mutant

50µg

5525

list186

FIMBRIAE 2/3 from B. pertussis

50µg

5950

list187

Pertactin from Bordetella pertussus (69 kDa Protein)

50µg

4590

list193

Tetanus Toxin C Fragment

10µg

9350

list201

LPS from Escherichia coli O111:B4

5mg

3230

list206

LPS, Escherichia coli 0157:H7

10.0mg

4760

list225

LPS from Salmonella typhimurium

5mg

2890

list301

LPS from Escherichia coli J5 (Rc)

5mg

2890

list302

LPS from Escherichia coli K12, D31m4 (Re)

5mg

2890

list304

LPS from Salmonella minnesota R595 (Re)

5mg

2890

list314

LPS from Escherichia coli K12 strain LCD25

1mg

2890

list400

HPT™ LPS, highly purified from Bordetella Pertussis 165

1mg

5100

list401

Lipid A monophosphoryl from Salmonella minnesota R595

1mg

3400

list421

Ultra Pure LPS from Escherichia coli O111:B4

1mg

3570

list423

Ultra Pure LPS from Escherichia coli O55:B5

1mg

3570

list433

LISTÔ HPTÔ, LPS, highly purified Escherichia coli O113 LPS

1mg

4080

list434

Ultra Pure LPS from Salmonella minnesota R595 (Re)

1mg

3400

list520

SNAPtide® Peptide Substrate (o-Abz/Dnp)  (U.S. Patent #6,504,006)

200nmoles

9775

list521

SNAPtide® Peptide Substrate (FITC/DABCYL)  (U.S. Patent #6,504,006)

200nmoles

8500

list523

SNAPtideÒ Peptide Substrate flP6 (DABCYL/5-IAF), U.S. Patent Pending #61/252,675

200nmoles

8500

list525

Control Peptide for SNAPtideÒ #520

200nmoles

8500

list526

Control Peptide for SNAPtide® #521

200nmoles

8500

list528

Unquenched Calibration Peptide for SNAPtide®  521

50nmoles

2890

list529

Unquenched Calibration Peptide for SNAPtide®  520

50nmoles

2890

list530

MAPKKide® Peptide Substrate (o-Abz/Dnp)

200nmoles

5100

list531

MAPKKide® Peptide Substrate  (DABCYL/FITC)

200nmoles

5100

list532

MAPKKide® Plus (AMC) Specific Substrate for Anthrax Lethal Factor

100nmoles

4250

list539

Unquenched Calibration Peptide for MAPKKideÒ 530

50nmoles

2890

list540

VAMPtide® Peptide Substrate (o-Abz/Dnp)

200nmoles

8500

list541

VAMPtide® Peptide Substrate (FITC/DABCYL)

200nmoles

8500

list542

VAMPtide® Peptide Substrate (PL 150, Pya/Nop)

200nmoles

8500

list549

Calibration  Fluorophore for VAMPtideÒ 540

100nmoles

2890

list550

SNAP Etide® Peptide Substrate (o-Abz/Dnp)

100nmoles

6800

list560

SYNTAXtideÒ Peptide Substrate (o-Abz/Dnp) for C. botulinum Type C

200nmoles

8500

list703

Anti-Cholera Toxin B Subunit (Goat)

0.1ml

3060

list752

Anti-Toxin A from Clostridium difficile (Goat)

0.5ml

3230

list760

Anti-Exotoxin A (Goat)

0.5ml

3400

list781

Anti-Protective Antigen from Bacillus anthracis (Goat) affinity purified, Liquid6,7

0.1mg

7055

list100B

Cholera Toxin (Azide Free)1

1mg

3400

list101B

Cholera Toxin1

1mg

3400

list101C

Cholera Toxin1

2mg

5355

list116L

Alpha Toxin from C. septicum4,6,7

50µg

4930

list126A

Epsilon Toxin from C. perfringens1,4,8

0.1mg

5950

list128A

Botulinum Neurotoxin Type A Complex from Clostridium botulinum1,3

10µg

2890

list128C

Botulinum Neurotoxin Type A Complex from Clostridium botulinum1,3

100µg

5440

list130A

Botulinum Neurotoxin Type A from Clostridium botulinum1,3

10µg

5440

list130B

Botulinum Neurotoxin Type A from Clostridium botulinum1,3

100µg

13600

list133L

Botulinum Neurotoxin Type A Toxoid, Liquid6,7

10µg

5440

list136A

Botulinum Neurotoxin Type B. from Clostridium botulinum 1,3

10µg

5100

list136B

Botulinum Neurotoxin Type B, from Clostridium botulinum1,3

100µg

17000

list138A

Botulinum Neurotoxin Type B Complex, Nicked, from Clostridium botulinum1,3

10µg

2890

list138B

Botulinum Neurotoxin Type B Complex, Nicked, from Clostridium botulinum1,3

100µg

7225

list140A

Botulinum Neurotoxin Type E, Nicked, Complex from Clostridium botulinum1,3

10µg

2890

list140B

Botulinum Neurotoxin Type E, Nicked, Complex from Clostridium botulinum1,3

100µg

8925

list141A

Botulinum Neurotoxin Type E, Nicked, from Clostridium botulinum1,3

10µg

8075

list146A

Botulinum Neurotoxin Type D, Nicked, Recombinant from Clostridium botulinum1,3

10µg

5355

list149A

Diphtheria Toxin CRM Mutant

0.25 mg

8500

list152C

Toxin A from Clostridium difficile

100µg

9010

list154A

Toxin B Toxoid from Clostridium difficile

20µg

2890

list15

Toxin B  from Clostridium difficile

2µg

2890

list155B

Toxin B  from Clostridium difficile

20µg

8500

list155C

Toxin B  from Clostridium difficile

200µg

15300

list155L

Toxin B from Clostridium difficile, Liquid6,7

50µg

9860

list157A

Binary  Toxin from Clostridium difficile, A Subunit

20µg

5950

list158A

Binary  Toxin from Clostridium difficile, B Subunit

40µg

5950

list159A

Glutamate Dehydrogenase (GDH) from Clostridium difficile6,7

0.1mg

4930

list169A

Anthrax Lethal Factor (LF-A) , Recombinant from Bacillus anthracis Native Sequence

0.1mg

3060

list169B

Anthrax Lethal Factor (LF-A),Recombinant from Bacillus anthracis Native Sequence

1mg

12750

list169L

 Anthrax Lethal Factor (LF-A),Recomb.from Bacillus anthracis 5,7

0.2 mg

5950

list171E

Anthrax Protective Antigen (PA), Recombinant from Bacillus anthracis

0.5mg

8755

list172B

Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis

1mg

12750

list172C

Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis

10mg

39525

list172L

Lethal Factor, Recomb from Bacillus anthracis, froz liq 5,7

1.0 mg

12750

list173B

Anthrax Edema Factor (EF), Recombinant Mutant S447N  from Bacillus anthracis

0.5mg

16150

list176A

Anthrax Lethal Factor (LF), Recombinant, Mutant E687C from Bacillus anthracis

0.1mg

5100

list176B

Anthrax Lethal Factor (LF), Recombinant, Mutant E687C from Bacillus anthracis

1mg

16150

list177A

Anthrax Protective Antigen Fragment (PA 20) from Bacillus anthracis

50µg

5950

list177B

Anthrax Protective Antigen Fragment (PA 20) from Bacillus anthracis

 0.25mg

11050

list178A

Anthrax Edema Factor (EF), Recombinant from Bacillus anthracis

0.1mg

2890

list179A

Pertussis Toxin Islet Activating Protein (in glycerol)6,7

50µg

4845

list188L

Adenylate Cyclase Toxin from B. pertussis, Recombinant, Frozen Liquid5,7

50µg

5270

list190A

Tetanus Toxin2

25µg

2890

list190B

Tetanus Toxin2

100µg

9350

list191A

Tetanus Toxoid

25µg

4675

list191B

Tetanus Toxoid

100µg

13600

list196A

C-fragment, FITC Conjugate

10µg

6800

list203A

LPS, Escherichia coli O55:B5

2.5 mg

3060

list500A

SNAP-25 Recomb Protein Substrate for C. botulinum Type A and E Neurotoxin

100µg

5525

list510A

GST Synaptobrevin-2 Protein Recomb. Protein Substrate for C. botulinum Type B,D and F

100µg

5950

list610A

Botulinum Neurotoxin Type A Light Chain, Recombinant1

10µg

4760

list611A

Botulinum Neurotoxin Type A Light Chain, GST Fusion, Recombinant1

15µg

4760

list612A

Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain1

50µg

4760

list613A

Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain, GST Fusion1

50µg

4760

list620A

Botulinum Neurotoxin Type B Light Chain, Recombinant1

10µg

8500

list622A

Botulinum Neurotoxin Type B Heavy Chain, Recombinant, Binding Domain1

50µg

4760

list623A

Botulinum Neurotoxin Type B Heavy Chain, Recombinant, Binding Domain, GST Fusion1

50µg

4760

list62

Botulinum Neurotoxin Type C Light Chain, Recombinant1

10µg

8500

list630A

Botulinum Neurotoxin Type D Light Chain, Recombinant1

10µg

5695

list650A

Tetanus Toxin Light Chain, Recombinant

10µg

3825

list690B

Receptor for C. botulinum Type A Neurotoxin GST-SV2c luminal domain
(U.S. Patent #8,476,024)

100nmoles

6800

list730A

Anti-Botulinum Neurotoxin, Type A (Chicken lgY), Liquid6,7

0.1mg

5610

list731L

Anti-Botulinum Neurotoxin, Type A (Mouse lgG monoclonal F1-40), Liquid6,7

0.1mg

5950

list736A

Anti-Botulinum Type B (Chicken lgY), Liquid6,7

0.1mg

5950

list753A

Anti-Clostridium difficile Toxin A (Chicken lgY), Liquid6,7

0.1mg

5780

list754A

Anti-Clostridium difficile Toxin B (Chicken lgY), Liquid6,7

0.1mg

5780

list756A

Anti-Clostridium difficile Glutamate Dehydrogenase, lgY, Liquid6,7

0.1mg

5780

list757A

Anti-Clostridium difficile Binary Toxin A subunit (Chicken lgY), Liquid6,7

0.1mg

5780

list758A

Anti-Clostridium difficile Binary Toxin B subunit (Chicken lgY), Liquid6,7

0.1mg

5780

list759A

Biotinylated Anti-Clostridium difficile Binary Toxin B subunit (Chicken lgY), Liquid6,7

0.1mg

5780

list761L

Anti-Shiga Toxin 1 (Rabbit), lgG, Liquid6,7

0.5mg

3400

list765L

Anti-Shiga Toxin 2 (Rabbit), IgG, Liquid6,7

0.5mg

2890

list766L

Anti-Shiga Toxin, Camelid Antibody, VHH, Liquid6,7

0.5mg/ml

5950

list768L

Biotinylated Anti-Lethal Factor from B. anthracis, IgY, Liquid6,7

0.1mg

5950

list769B

Anti-Lethal Factor from Bacillus anthracis (Chicken lgY), Liquid6,7

0.2mg

8500

list771B

Anti-Protective Antigen from Bacillus anthracis (Goat)

1mg

2890

list772B

Anti-Lethal Factor from Bacillus anthracis (Goat)

1.0 mg

2890

list773L

Anti-Edema Factor from Bacillus anthracis (Goat), Liquid6,7

1mg

2890

 

 

 

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上海金畔生物科技有限公司是实验试剂一站式采购服务商

1：强大的进口辐射能力，血清、抗体、耗材、大部分限制进口品等。

2：产品种类齐全，经营超过700多品牌，基本涵盖所有生物实验试剂耗材。

3：提供加急服务，货品一般1-2周到货。

4：富有竞争良好的信誉，大部分客户提供货到付款服务。客户包括清华、北大、交大、复旦、中山等100多所高校，ROCHE，阿斯利康、国药、fisher等知药企。

6：我们还是Santa,Advanced Biotechnologies Inc,Athens Research & Technology,bangs,BBInternational,crystalchem,dianova,FD Neurotechnologies,Inc. FormuMax Scientific,Inc, Genebridege, Glycotope Biotechnology GmbH; iduron,Innovative Research of America, Ludger, neuroprobe,omicronbio, Polysciences,prospecbi, QA-BIO,quickzyme,RESEARCH DIETS,INC,sterlitech；sysy,TriLink BioTechnologies,Inc；worthington-biochem,zyagen等几十家国外公司代理。

7：我们还是invitrogen,qiagen,MiraiBioam,sigma;neb,roche,merck, rnd,BD, GE,pierce,BioLegend等知*批发，欢迎合作。

 

重组霍乱毒素B亚基

发表于由

上海金畔生物科技有限公司提供重组霍乱毒素B亚基 ，欢迎访问官网了解更多产品信息。

产品编号 D10692
英文名称 Recombinant Cholera Toxin B subunit
中文名称 重组霍乱毒素B亚基
别    名 CHOLERA TOXIN B SUBUNIT; Cholera Toxin B subunit; CTxB; Choleragenoid; CTB;   霍乱毒素亚型B(CTB); 霍乱毒素B亚基; 霍乱毒素B亚单位;
浓    度 1mg/ml
保存条件 Store at 2-8℃. DO NOT FREEZE.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 基本信息：
CAS：131096-89-4
分子量：11 kDa
种属：Vibrio cholerae
来源：E. coli.
内毒素：Less than 0.1EU/µg of rCTB as determined by LAL method.
纯度：>98% by SDS-PAGE and HPLC analyses.
外观：Sterile colorless liquid.
缓冲体系：Supplied as a 0.2µM filtered solution in 5mM PB, pH7.0, 75mM NaCl, with 50% glycerol. (Sodium azide free.)
描述：霍乱毒素B亚基 (Cholera Toxin B subunit）属于毒素的AB5-亚单位家族。天然六聚体蛋白的分子量约为85 kDa，包含两个亚单位。它由负责ADP核糖基化活性的单个a亚单位（~27.2 kDa）和五个B亚单位（~11.6 kDa）组成，排列为五聚环，具有明显的5倍对称性，与细胞表面受体结合和酶组分的后续内化（跨膜转运）有关。

背景资料：
Cholera toxin is protein complex secreted by the bacterium Vibrio cholerae. CTX is responsible for the massive, watery diarrhea characteristic of cholera infection. The cholera toxin is an oligomeric complex made up of six protein subunits: a single copy of the A subunit (part A, enzymatic), and five copies of the B subunit (part B, receptor binding), denoted as AB5. Subunit B binds while subunit A activates the G protein which activates adenylate cyclase. The five B subunits – each weighing 11 kDa, form a five-membered ring. The A subunit which is 28 kDa, has two important segments. The A1 portion of the chain (CTA1) is a globular enzyme payload that ADP-ribosylates G proteins, while the A2 chain (CTA2) forms an extended alpha helix which sits snugly in the central pore of the B subunit ring. This structure is similar in shape, mechanism, and sequence to the heat-labile enterotoxin secreted by some strains of the Escherichia coli bacterium.

氯毒素

发表于由

上海金畔生物科技有限公司提供氯毒素 ，欢迎访问官网了解更多产品信息。

产品编号 D50500
英文名称 Chlorotoxin
中文名称 氯毒素
别    名 CLTX; CLTX (EGYPTIAN SCORPION); Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-CysGly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg-NH2 (Disulfide bridge: Cys2-Cys19,Cys5-Cys28,Cys16-Cys33,Cys20-Cys35);   氯代毒素; U251MG细胞迁移抑制剂;
保存条件 Store at -20℃.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 基本信息：
CAS：163515-35-3
分子式：C158H256N52O48S11
分子量：3995.7
纯度：97%
级别：BR
序列：MCMPCFTTDHQMARKCDDCCGGKGRGKCYGPQCLCR-NH2 (Disulfide bridge: Cys2-Cys1 9,Cys5-Cys28,Cys16-Cys33,Cys20-Cys35); Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-CysGly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-Pro-Gln-Cys-Leu-Cys-Arg-NH2 (Disulfide bridge: Cys2-Cys19,Cys5-Cys28,Cys16-Cys33,Cys20-Cys35); 
性状：乳白色粉末

产品简介：
氯毒素（Chlorotoxin）是从雷蛇属以色列蝎子的毒液中提取的由36个氨基酸组成的肽段，具有抗癌活性。Chlorotoxin是氯离子通道 (chloride channel) 阻断剂。U251MG 细胞迁移抑制剂。
作⽤靶点：Chloride Channel
作⽤通路：Membrane Transporter/Ion Channel
体外研究：
Chlorotoxin (Chlorotoxin) preferentially binds to tumor cells and has been harnessed to develop an imaging agent to help visualize tumors during surgical resection. In addition, chlorotoxin has potential as a vehicle to deliver anti-cancer drugs specifically to cancer cells. Chlorotoxin is shown to bind glioma cells, but is unable to bind normal rat astrocytes and Te671, a human rhabdomyosarcoma cell line. Chlorotoxin inhibits the migration of U251MG (glioma) cells, with an IC50 of 600 nM. Chlorotoxin binds to glioma cells is specific and involves high affinity (Kd=4.2 nM) and low affinity (Kd=660 nM) binding sites.Small conductance chloride channels are shown to be potently blocked by Chlorotoxin. Chlorotoxin has been used as a general pharmacological tool to investigate the function of chloride channels.
体内研究：
Chlorotoxin shows insecticidal activity on insects and other invertebrates. After the administration of I-Chlorotoxin to tumor-bearing mice, the peptides accumulated within the tumor.Chlorotoxin selectively accumulates in the brain of tumor-bearing mice with calculated brain: muscle ratios of 36.4% of injected dose/g (ID/g), as compared to 12.4%ID/g in control animals.