4-(2-氨乙基)苯磺酰氟盐酸盐

上海金畔生物科技有限公司提供4-(2-氨乙基)苯磺酰氟盐酸盐 ,欢迎访问官网了解更多产品信息。

产品编号 D50381
英文名称 AEBSF hydrochloride
中文名称 4-(2-氨乙基)苯磺酰氟盐酸盐
别    名 AEBSF; AEBSF, Hydrochloride; AEBSF HCl;   4-(2-氨乙基)苯磺酰氟盐酸盐; 苯磺酰氟盐酸盐; 苯磺酰氟盐; 苯磺酰氟; AEBSF丝氨酸抑制剂; AEBSF丝氨酸蛋白酶抑制剂;
保存条件 Store at -20℃ for 3 year(Powder); In DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 基本信息:
CAS:30827-99-7
分子式:C8H10FNO2S·HCl
分子量:239.69
MDL:MFCD00132962
级别:>97% by HPLC
溶解性:溶于水。H2O:可溶性50mg/mL(如果在pH值低于7的条件下冷藏,则可稳定长达6个月。如果要求pH值大于7,应在使用前进行pH值调整。)
性状:白色粉末
敏感性:易吸潮
作用靶点:Thrombin; Influenza Virus;
作用通路:Metabolic Enzyme/Protease; Anti-infection;
用途:蛋白酶抑制剂,是一种水溶性的乳糜蛋白酶、激肽释放酶、纤溶酶、凝血酶、胰蛋白酶和相关溶栓酶的特异性不可逆抑制剂。PMSF和DFP的无毒替代品。AEBSF 在PH7的水溶液中4℃可保持稳定1-2个月,但在低PH条件下更稳定。推荐使用浓度为:0.1-1.0 mM。AEBSF 已用于细胞培养,使用浓度可达 0.25mM。

体外研究:
AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural. AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β. AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern.

体内研究:
AEBSF (76.8 mg/kg daily i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection. AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model.