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SiliaBond Carbonate (CO3) (R66030B)
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Product Number | Quantity | ||
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R66030B-10G | 10 g |
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R66030B-25G | 25 g |
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R66030B-50G | 50 g |
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R66030B-100G | 100 g |
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R66030B-250G | 250 g |
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R66030B-500G | 500 g |
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R66030B-1KG | 1 kg |
Details
SiliaBond® Carbonate (Si–CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.
SiliaBond Carbonate is also very efficient at scavenging boronic acids: 99% removal of phenylboronic acid with one equivalent in DCM at room temperature after 1h. Si-CO3 can free base ephedrine hydrochloride quantitatively (100% yield determined by 1H NMR) using 4 equivalents at room temperature for two hours.
PRODUCT SPECIFICATIONS
MSDS-R66030B
APPLICATION NOTES
Scavenging Using SiliaBond Carbonate
RELATED PUBLICATIONS
- Org. Lett., 4 (2002) 1167
- Org. Lett., 5 (2003) 4721
- J. Comb. Chem., 9 (2007) 677
- J. Comb. Chem., 10 (2008) 235
- Bioorg. Med. Chem. Lett., 20 (2010), 232
Additional Information
Particle Shape | Irregular |
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Array | Carbonate (CO3) |
Family / Formats | SiliaBond® (Functionalized Silicas) |
Particle Size | 40 – 63 µm / 230 – 400 mesh |
Pore Size | 60 Å |
Endcapping | Endcapped |
Storage Condition | Keep dry |