上海金畔生物科技有限公司提供2,3-DCPE盐酸盐 ，欢迎访问官网了解更多产品信息。
| 产品编号 | D50449 |
| 英文名称 | 2,3-DCPE hydrochloride |
| 中文名称 | 2,3-DCPE盐酸盐 |
| 别 名 | 2,3-DCPE; |
| 保存条件 | Store at -20℃ |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 | CAS号：418788-90-6 分子式：C11H15Cl2NO2.HCl 分子量：300.61 纯度：99%(HPLC) 熔点：139-142℃ 沸点：429.8℃ at 760 mmHg 溶解性：Soluble in water (>25 mg/ml), ethanol (~20 mg/ml), DMSO (~20 mg/ml), DMF (~20 mg/ml), and PBS (pH7.2) (~10 mg/ml). 产品描述：2,3 DCPE displays anticancer agent properties and induces ERK activation. Causes apoptosis in many tumor cell lines and is known to specifically cleave caspase-8, caspase-3, caspase-9, and poly(ADP-ribose) polymerase in cancer cells, but not in human fibroblasts. Shown to reduce the protein level of Bcl-XL. Triggered cell death in OAW42-R ovarian carcinoma cells with inhibition of Bcl-2 expression and increased cytotoxic effect of cisplatin in OAW42-R resistant cells. 2,3-DCPE reported to induce S-phase arrest and upregulate p21. IC50：LoVo colon cancer cell line: IC50 = 0.89 µM (human); normal fibroblasts: IC50 = 12.6 µM (human) 用途：A compound that induces both upregulation and S-phase arrest in p21. |