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Enzyme Research 是一家拥有超过25年的酶研究的实验室,生产和开发多种用于基本凝血研究的多种酶和辅因子。在过去的十年Enzyme Research Laboratories为科学家参与止血和血栓形成的研究提供了宝贵支持。Enzyme Research通过不断追求产品的zui高品质,赢得了世界各地凝血研究实验室的信任。
Enzyme Research Laboratories为生物技术公司,制药行业、医院和大学的研究实验室提供用于的纯化抗凝因子。除了其制造能力,Enzyme Research Laboratories也创新研发领域中的血液凝固技术。
Human GPIIbIIIa
GP2b3a Human GPIIbIIIa
Plaet membrane glycoproteins are involved in plaet adhesion and aggregation. Glycoproteins IIb and IIIa (GPIIb and GPIIIa) constitute the fibrinogen receptor and are required for plaet aggregation. ERL offers GPIIbIIIa purified from human plaets. Glycoprotein IIb consists of 2 disulfide-linked subunits GPIIb (MW = 125,000) and GPII (MW= 23,000) while GPIIIa has only one polypeptide chain (MW= 108,000). GPIIbIIIa migrates on gels as follows: GPIIb 136,000 non-reduced and 125,000 reduced. GPIIIa is 97,000 non-reduced and 108,000 reduced. Protein concentration is determined via the Bradford method.
Buffer Composition = 20 mM Tris-HCl/0.1 M NaCl/0.1% Triton X-100/
1 mM CaCl2/0.05% NaN3/50% glycerol/ pH 7.4
*Extinction Coefficient (1%) = 9.1